专利名称：3-[alpha-(3,5-di-t-butyl-4-hydroxyphenyl)-alkanoyl]pyrroles, their de-oxy analogs, andtherapeutic uses thereof
发明人：Muchowski, Joseph M.,Greenhouse, Robert
J.,Young, John M.,Murthy, D.V.
Krishna,Vickery, Brian H.,Walker, Keith A.M.,Chin, Ruei-Chen,Prince,
Anthony,Povzhitkov, Moysey M.,Gardner,John O.
申请号：EP87117332.4申请日：19871124公开号：EP0269981A1公开日：19880608
摘要：3-[ω-(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]pyrroles and their de-oxyanalogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-di-t-butyl-4-hydroxyphenyl)-1-oxoethyl]pyrrole, are useful for the treatment ofpsoriasis or other allergic conditions such as conjunctivitis, bronchial asthma and
inflammatory bronchial diseases; inflammatory bowel disease; inflammatory diseases; asanalgesic and antipyretic agents; in bone diseases such as osteoporosis, periodontitis,tumor-related hypercalcemia, osteopetrosis, and Paget's Disease; and in ischemic heartdisease including myocardial ischemia and myocardial infarction.
申请人：SYNTEX (U.S.A.) INC.
地址：3401 Hillview Avenue Palo Alto California 94303 US
国籍：US
代理机构：Barz, Peter, Dr.
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