Product and process for t cell regulation

专利名称：Product and process for t cell regulation发明人：JOHN W KAPPLER,PHILIPPA MARRACK申请号：AU2094295申请日：19950303公开号：AU2094295A公开日：19950918

摘要：The present invention relates to a product and process for regulating theactivity of T cells using major histocompatibility complexes (MHC) stably linked toantigenic peptides. Disclosed is an antigenic peptide covalently linked to a majorhistocompatibility complex (MHC) protein by a novel linker, thereby enabling theformation of a stable peptide-MHC complex, alone or in combination with additionalMHC protein chains, capable of being recognized by a T cell receptor (TCR). Alsodisclosed is a nucleic molecule having a sequence encoding a Peptide-L-MHC moleculecomprising an antigenic peptide joined by a linker to an MHC segment. The invention isadditionally directed to formulations comprising an antigenic peptide joined by a linkerto an MHC segment anchored in a lipid-containing substrate. Pharmaceutical reagentsare also disclosed which contain an antigenic peptide joined by a linker to an MHCsegment combined with a suitable carrier that is capable of presenting the Peptide-L-MHC molecule so that it is capable of being recognized by a T cell receptor.

申请人：NATIONAL JEWISH CENTER FOR IMMUNOLOGY AND RESPIRATORYMEDICINE

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