CLOSTRIDIUM DIFFICILE DEHYDROGENASE AND TOXIN AS A

专利名称：CLOSTRIDIUM DIFFICILE DEHYDROGENASE

AND TOXIN AS A BIOMARKER

发明人：BOONE, James, Hunter,LYERLY, David,

M.,CARMAN, Robert, J.

申请号：EP12838635.6申请日：20121031公开号：EP2841593A1公开日：20150304

摘要：Clostridium difficile disease involves a range of clinical presentations rangingfrom carrier status with other causes of symptoms to mild and self-limiting diarrhea tolife-threatening pseudomembranous colitis and megacolon. Cases of C. difficile aretreated differently depending on the presence and then the severity of disease. Patientsthat are carriers may not receive treatment with concern of causing the disease. Mild tomoderate cases may be treated with metronidazole while severe and relapsing cases areoften treated with vancomycin or fidaxomicin. Current molecular assays are highlysensitive for detecting toxigenic C. difficile and cannot rule out carrier status. Utilizationof a biomarker panel that includes C. difficile antigen (GDH), toxins A and B, and fecallactoferrin allows clinicians to differentiate between a carrier state and active state of C.difficile and allows for monitoring to evaluate the effectiveness of treatment.

申请人：TechLab, Inc.

地址：2001 Kraft Drive Blacksburg, VA 24060 US

国籍：US

代理机构：Fyfe, Fiona Allison Watson

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