PERCUTANEOUSLY ABSORBABLE PREPARATION

专利名称：PERCUTANEOUSLY ABSORBABLE

PREPARATION

发明人：HASHIMOTO, Masaki,MANO,

Mitsuhito,AMANO, Mutsuki,WAKIYA, Takeshi

申请号：EP95925997.9申请日：19950720公开号：EP0773028A1公开日：19970514

摘要：A percutaneously absorbable preparation which contains norethisterone,estradiol or ester thereof, each of which is highly absorbable percutaneously, can readilybe stuck to the skin, and is lowly skin irritating. It is prepared by applying a pressure-sentitive adhesive layer comprising a drug and a pressure-sensitive adhesive to one sideof a support. The drug comprises at least one member selected from amongnorethisterone, estradiol and pharmacologically acceptable esters thereof, while theadhesive comprises a copolymer composed of 20-55 mol.% of vinylpyrrolidone and 80-45mol.% of alkyl (C-C) (meth)acrylate. The adhesive layer further contains a sorbifacientcomprising 0.1-10 wt.% of at least one member selected from among dicarboxylic acids,hydroxy carboxylic acids, plyoxyethylene alkyl ethers and amide compounds and 5-40wt.%, both based on the adhesive layer, of a higher fatty acid ester prepared from a C-Cfatty acid and a C-C alcohol and also contains a cohesive force improver.

申请人：SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA

地址：4-4 Nishitenma 2-chome, Kita-ku Osaka-shi, Osaka 530 JP

国籍：JP

代理机构：Hubert, Philippe

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