专利名称：METHOD FOR THE PRODUCTION OF
INSULIN-LIKE GROWTH FACTOR-1
发明人：Stephan Fischer,Friederike Hesse,Hendrik
Knoetgen,Kurt Lang,Joerg Thomas
Regula,Christian Schantz,Andreas Schaubmar
申请号：US12438154申请日：20070829
公开号：US20100121036A1公开日：20100513
摘要：Method for the production of IGF-I, characterized by cultivating a prokaryotichost cell comprising an expression vector containing a nucleic acid encoding a fusionprotein comprising said IGF-I N-terminally linked to the C-terminus of a propeptide,whereby said propeptide ends C-terminally with amino acids -Y-Pro, wherein Y is selectedfrom the group consisting of Pro, Pro-Ala, Pro-Gly, Pro-Thr, Ala-Pro, Gly-Pro, Thr-Pro,Arg-Pro, or Pro-Arg-Pro, recovering and cleaving said fusion protein with IgA protease,and recovering said IGF-I. IGF-I is useful for the treatment of neurodegenerativedisorders like Alzheimer's Disease.
申请人：Stephan Fischer,Friederike Hesse,Hendrik Knoetgen,Kurt Lang,Joerg ThomasRegula,Christian Schantz,Andreas Schaubmar
地址：Polling DE,Muenchen DE,Penzberg DE,Penzberg DE,Muenchen DE,PenzbergDE,Penzberg DE
国籍：DE,DE,DE,DE,DE,DE,DE
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