METHODS AND REAGENTS FOR INHIBITING FURIN ENDOPROT

专利名称：METHODS AND REAGENTS FOR INHIBITING

FURIN ENDOPROTEASE

发明人：THOMAS, Gary,ANDERSON, Eric D.,THOMAS,

Laurel,HAYFLICK, Joel S.,NELSON,Jay,STENGLEN, Stephan G.

申请号：EP94907783.8申请日：19940107公开号：EP0678121B1公开日：20030625

摘要：This invention relates to methods and reagents for inhibiting furinendoprotease activity and specifically for inhibiting furin endoprotease-mediatedmaturation of bioactive proteins in vivo and in vitro. The invention specifically providesproteins capable of inhibiting furin endoprotease activity. Particularly provided are α1-antitrypsin variants that specifically inhibit furin endoprotease activity. Methods for usingfurin endoprotease inhibition to attenuate or prevent viral protein maturation, andthereby alleviate viral infections, are provided. Also provided are methods for using furinendoprotease inhibition to attenuate or prevent proteolytic processing of bacterialtoxins, thereby alleviating bacterial infections. Methods are also provided to inhibitproteolytic processing of biologically active proteins and peptides. The invention alsoprovides pharmaceutically acceptable compositions of therapeutically effective amountsof furin endoprotease inhibitors.

申请人：OREGON STATE

地址：US

国籍：US

代理机构：Bizley, Richard Edward

更多信息请下载全文后查看