您好,欢迎来到尚车旅游网。
搜索
您的当前位置:首页Processes for the preparation of 5-amino-4-hydroxy

Processes for the preparation of 5-amino-4-hydroxy

来源:尚车旅游网
专利内容由知识产权出版社提供

专利名称:Processes for the preparation of 5-amino-4-hydroxyvaleric acid derivatives

发明人:Peter Herold,Christof Angst申请号:US07/0837申请日:19870813公开号:US0477A公开日:19900206

摘要:The invention relates to novel processes and intermediates for the preparationof 5-amino-4-hydroxyvaleric acid derivatives of the formula ##STR1## in which R.sup.1represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl,aryl-lower alkyl or the radical of a natural amino acid, R.sup.2 represents hydrogen,optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl,amino, hydroxy, mercapto, sulphinyl, sulphonyl or the radical of a natural amino acid, andR.sup.3 represents optionally substituted hydroxy or amino, by sigmatropic

rearrangement of a suitable allyl ester, halolactonisation of the resulting &ggr;,&dgr;-unsaturated acid or of a suitable derivative thereof, exchange of halogen for a nitrogen-containing nucleophile, opening of the lactone ring and freeing of the amino group.Compounds of the formula I are starting materials for the preparation of renin-inhibitorswhich have an anti-hypertensive action.

申请人:CIBA-GEIGY CORPORATION

代理人:JoAnn Villamizar,Irving M. Fishman

更多信息请下载全文后查看

因篇幅问题不能全部显示,请点此查看更多更全内容

Copyright © 2019- sceh.cn 版权所有 湘ICP备2023017654号-4

违法及侵权请联系:TEL:199 1889 7713 E-MAIL:2724546146@qq.com

本站由北京市万商天勤律师事务所王兴未律师提供法律服务