STANDARDIZED EVALUATION OF THERAPEUTIC EFFICACY BA

专利名称：STANDARDIZED EVALUATION OF

THERAPEUTIC EFFICACY BASED ONCELLULAR BIOMARKERS

发明人：Lesko, Stephen A.,Ts'O, Paul O.P.申请号：EP04715624.5申请日：20040227公开号：EP1604184A2公开日：20051214

摘要：The present invention provides materials and methods for predicting theresponse of a disease state to a therapeutic agent. A targeting moiety specific for abiological marker is labeled with a reporter moiety and used to analyze cellscharacteristic of the disease state. The output of the reporter moiety, which may befluorescence intensity, is compared to the output of reference standard analyzed undersimilar or identical conditions. The use of a reference standard allows biomarkerreporting to be normalized. Biomarker values can then be correlated from sample tosample and from laboratory to laboratory based on quantitative calibration on auniversal reference standard.

申请人：Lesko, Stephen A.,Ts'O, Paul O.P.

地址：7406 Knollwood Road Baltimore, MD 21286 US,9039 Furrow Avenue Ellicott city,MD 21042-1841 US

国籍：US,US

代理机构：Schlich, George William

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