ANALOGS OF (1S, CIS)-4-(2-AMINO-9H-PURIN-9-YL)-2-C

专利名称：ANALOGS OF (1S, CIS)-4-(2-AMINO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL AS ANTIVIRAL

发明人：Daluge, Susan Mary,c/o Glaxo Wellcome Inc.申请号：EP00984009.1申请日：20001207公开号：EP1235833A1公开日：20020904

摘要：Refers to phosphoramidates analogues modified 6 - (1S, CIS) - 4 - (2 - amino - 9hpurin - 9 - yl) - methanol - 1 - 2 - only of formula I, wherein R1 is H, C6 C14 aryl,heteroaryl; R2 and R3 are h,C1 C8 alkyl, cycloalkyl C3, C8, alquenilo C2 - C5 - C8 C8,cicloalquenilo, among others; it is nr8r9 0R8 SR8, R4, R8 and R9 are; h, alkyl C8 alqueniloC1 - C2, C8, among others; R5 C1 is H, alkyl C8Aryl C6 C1, R2 and R5 R3 and R5 ortogether form a Ring of 5-6 members; X is c1-c6 alkoxy, heterocycle, imidazolilo, amongothers; when X is not replaced with amino ciclopropilo.Preferred compounds are(methoxy phenyl - [L -] alaninil phosphoramidate (1S), CIS) - 4 - [2 - amino - 4 - (1 -azetidinil) - 9h purin - 9 - yl] - only - 1 - 2 - phenyl Methanol; or - [methoxy (- L - alaninilphosphoramidate (1S)],CIS) - 4 - [2 - (6 - amino - ciclopropilmetilamino) - 9h purin - 9 - yl] -2 - only - 1 - methanol, among others. Compound I can be useful for the treatment of HIVinfections, hepatitis B, C

申请人：GLAXO GROUP LIMITED

地址：Glaxo Wellcome HouseBerkeley Avenue Greenford, Middlesex UB6 ONN GB

国籍：GB

代理机构：Crawley, Karen Anne

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